Personally, I'd like Psychonauts to have a potential remake and hopefully it could do well this time. Wouldn't be too hard, got the plot and everything right there. Then again, it'd me more of an HD upscale, I guess.
Still, if we're talkin' about full on reboot, I'd love to see a worthwhile and not half baked attempt at reviving the Crash Bandicoot franchise. I miss it so much.